17-β-Estradiol activates maxi-K channels through a non-genomic pathway in human breast cancer cells
نویسندگان
چکیده
منابع مشابه
Ca2+ influx through stretch-activated cation channels activates maxi K+ channels in porcine endocardial endothelium.
The endocardial endothelium is an important modulator of myocardial function. The present study demonstrates the existence of a stretch-activated Ca(2+)-permeable cation channel and of a Ca(2+)-activated K+ channel in the endocardial endothelium of the porcine right atrium. The stretch-activated channel is permeable for K+, Na+, Ca2+, and Ba2+, with mean conductances of approximately 32 pS for ...
متن کاملApoptotic ratios and mitotic abnormalities in 17-β-estradiol-transformed human breast epithelial MCF-10F cells.
Treatment of human breast epithelial cells MCF-10F with 17-β-estradiol has been reported to result in E2-transformed cells which have given rise to highly invasive C5 cells that in turn generate tumors in SCID mice. From these tumors, various cell lines, among which C5-A6-T6 and C5-A8-T8, were obtained. Although different phases of the tumorigenesis process in this model have been studied in mo...
متن کامل17-β estradiol protects ARPE-19 cells from oxidative stress through estrogen receptor-β.
PURPOSE To elucidate the mechanism of 17-β estradiol (17β-E(2))-mediated protection of retinal pigment epithelium (RPE) from oxidative stress. METHODS Cultured ARPE-19 cells were subjected to oxidative stress with t-butyl hydroxide or hydrogen peroxide in the presence or absence of 17β-E(2). Reactive oxygen species (ROS) were measured using H(2)DCFDA fluorescence. Apoptosis was evaluated by c...
متن کاملMultiple Facets of Maxi-K+ Channels
In the classic era of electrophysiology, two distinct classes of ion channels were thought to exist in cell membranes: one class accounted for the generation of action potentials and their propagation along nerve fibers (voltage-gated channels); the other class accounted for the electrical signals at the chemical synapses (transmitter-gated channels). The advances made for the last decades in t...
متن کاملEstradiol activates epithelial sodium channels in rat alveolar cells through the G protein-coupled estrogen receptor.
Female sex predisposes individuals to poorer outcomes during respiratory disorders like cystic fibrosis and influenza-associated pneumonia. A common link between these disorders is dysregulation of alveolar fluid clearance via disruption of epithelial sodium channel (ENaC) activity. Recent evidence suggests that female sex hormones directly regulate expression and activity of alveolar ENaC. In ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: FEBS Letters
سال: 2005
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2005.02.085